An Environmental Risk Assessment for Human-Use Trimethoprim in European Surface Waters
Identifieur interne : 000337 ( Main/Exploration ); précédent : 000336; suivant : 000338An Environmental Risk Assessment for Human-Use Trimethoprim in European Surface Waters
Auteurs : Jürg Oliver StraubSource :
- Antibiotics [ 2079-6382 ] ; 2013.
Abstract
An environmental risk assessment (ERA) for the aquatic compartment in Europe from human use was developed for the old antibiotic Trimethoprim (TMP), comparing exposure and effects. The exposure assessment is based on European risk assessment default values on one hand and is refined with documented human use figures in Western Europe from IMS Health and measured removal in wastewater treatment on the other. The resulting predicted environmental concentrations (PECs) are compared with measured environmental concentrations (MECs) from Europe, based on a large dataset incorporating more than 1800 single MECs. On the effects side, available chronic ecotoxicity data from the literature were complemented by additional, new chronic results for fish and other organisms. Based on these data, chronic-based deterministic predicted no effect concentrations (PNECs) were derived as well as two different probabilistic PNEC ranges. The ERA compares surface water PECs and MECs with aquatic PNECs for TMP. Based on all the risk characterization ratios (PEC÷PNEC as well as MEC÷PNEC) and risk graphs, there is no significant risk to surface waters.
Url:
DOI: 10.3390/antibiotics2010115
PubMed: 27029296
PubMed Central: 4790302
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An Environmental Risk Assessment for Human-Use Trimethoprim in European Surface Waters</title><author><name sortKey="Straub, Jurg Oliver" sort="Straub, Jurg Oliver" uniqKey="Straub J" first="Jürg Oliver" last="Straub">Jürg Oliver Straub</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27029296</idno><idno type="pmc">4790302</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790302</idno><idno type="RBID">PMC:4790302</idno><idno type="doi">10.3390/antibiotics2010115</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000082</idno><idno type="wicri:Area/Pmc/Curation">000082</idno><idno type="wicri:Area/Pmc/Checkpoint">000291</idno><idno type="wicri:Area/Ncbi/Merge">000427</idno><idno type="wicri:Area/Ncbi/Curation">000427</idno><idno type="wicri:Area/Ncbi/Checkpoint">000427</idno><idno type="wicri:Area/Main/Merge">000337</idno><idno type="wicri:Area/Main/Curation">000337</idno><idno type="wicri:Area/Main/Exploration">000337</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An Environmental Risk Assessment for Human-Use Trimethoprim in European Surface Waters</title><author><name sortKey="Straub, Jurg Oliver" sort="Straub, Jurg Oliver" uniqKey="Straub J" first="Jürg Oliver" last="Straub">Jürg Oliver Straub</name></author></analytic><series><title level="j">Antibiotics</title><idno type="eISSN">2079-6382</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>An environmental risk assessment (ERA) for the aquatic compartment in Europe from human use was developed for the old antibiotic Trimethoprim (TMP), comparing exposure and effects. The exposure assessment is based on European risk assessment default values on one hand and is refined with documented human use figures in Western Europe from IMS Health and measured removal in wastewater treatment on the other. The resulting predicted environmental concentrations (PECs) are compared with measured environmental concentrations (MECs) from Europe, based on a large dataset incorporating more than 1800 single MECs. On the effects side, available chronic ecotoxicity data from the literature were complemented by additional, new chronic results for fish and other organisms. Based on these data, chronic-based deterministic predicted no effect concentrations (PNECs) were derived as well as two different probabilistic PNEC ranges. The ERA compares surface water PECs and MECs with aquatic PNECs for TMP. Based on all the risk characterization ratios (PEC÷PNEC as well as MEC÷PNEC) and risk graphs, there is no significant risk to surface waters. </p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Straub, J O" uniqKey="Straub J">J.O. Straub</name></author><author><name sortKey="Hutchinson, T H" uniqKey="Hutchinson T">T.H. Hutchinson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Gros, M" uniqKey="Gros M">M. Gros</name></author><author><name sortKey="Petrovi, M" uniqKey="Petrovi M">M. Petrović</name></author><author><name sortKey="Barcel, D" uniqKey="Barcel D">D. Barceló</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X Q" uniqKey="Chen X">X.-Q. Chen</name></author><author><name sortKey="Cho, S J" uniqKey="Cho S">S.J. 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Reyes</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B. Wang</name></author><author><name sortKey="Selleck, E M" uniqKey="Selleck E">E.M. Selleck</name></author><author><name sortKey="Sommer, M O A" uniqKey="Sommer M">M.O.A. Sommer</name></author><author><name sortKey="Dantas, G" uniqKey="Dantas G">G. Dantas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Ahmad, A" uniqKey="Al Ahmad A">A. Al-Ahmad</name></author><author><name sortKey="Haiss, A" uniqKey="Haiss A">A. Haiss</name></author><author><name sortKey="Unger, J" uniqKey="Unger J">J. Unger</name></author><author><name sortKey="Brunswick Tietze, A" uniqKey="Brunswick Tietze A">A. Brunswick-Tietze</name></author><author><name sortKey="Wiethan, J" uniqKey="Wiethan J">J. Wiethan</name></author><author><name sortKey="Kummerer, K" uniqKey="Kummerer K">K. Kümmerer</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Straub, Jurg Oliver" sort="Straub, Jurg Oliver" uniqKey="Straub J" first="Jürg Oliver" last="Straub">Jürg Oliver Straub</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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